डॉ. विजय प्रताप सिंह M.SC, Ph.D & PDF

वैज्ञानिक - डी बी टी रामलिंगस्वामी फेलो

आईसीएमआर-राष्ट्रीय जनजाति स्वास्थ्य अनुसंधान संस्थान

प्रोफ़ाइल

Dr. Vijay Pratap Singh is currently working as Scientist/DBT-Ramalingaswami Fellow in the area of maternal-child health. After obtaining his post-graduate training in biotechnology from University of Jammu, Jammu and doctorate degree in life sciences from Jawaharlal Nehru University, New Delhi/ CSIR-Centre for Cellular and Molecular Biology, Hyderabad, he moved to Stowers Institute for Medical Research, Kansas City, USA for his post-doctoral training in the area of genome maintenance. He has joined ICMR-NIRTH in 2023 as Scientist/DBT-Ramalingaswami Fellow and working on role of genome maintenance in placental development and pregnancy complications.

शोध के विषय

Dr. Vijay Pratap Singh broad interest is in understanding the role of genome maintenance in the cells of the developing placenta, a highly polyploid organ system. His laboratory is using the diverse molecular, cellular, genetic, and proteomics tools available in human cells and M. musculus to identify the regulators of genome maintenance in different placental cell types. His research program has immediate implications for maternal-child health of tribal population but may also have broader implications for understanding fundamental molecular ties between genome maintenance and signalling that underlie aging and cancer

वैज्ञानिक कर्मचारी

N/A

विगत शोध छात्र

NA

जारी अनुसंधान परियोजनाएं

Role of genome maintenance in placental development and pregnancy complications

वर्तमान अनुसंधान सहयोगी

N/A

विगत अनुसंधान सहयोगी

समाचार में शोध

N/A

पुरस्कार / मान्यता / सम्मान

  • Selected for young investigator meeting organized by IndiaBiosciences 2024
  • Selected for “Placenta Biology Course” 2023- Centre for Trophoblast Research, University of Cambridge, UK
  • DBT-Ramalingaswami Fellowship, 2022
  • NIH New Investigator Travel Award, IFPA, 2021
  • Selected for “Developmental Origins of Health and Disease Course” 2021- Oregon Health & Science University, USA
  • Selected for “Mouse Development, Stem Cells, and Cancer Course” 2016 - Cold Spring Harbor Laboratory, USA
  • GATE- 2005 (All India Rank-17)
  • DBT- Junior Research Fellowship (2005)
  • CSIR- UGC Junior Research Fellowship- NET (2005)
  • Scholarship during M.Sc. from Department of Biotechnology, Government of India (2003)

संगठित कार्यशाला / सम्मेलन

N/A

शैक्षणिक योगदान

  • Supervisor of PhD thesis: Nil
  • Co-supervised Master Dissertation: 1
  • Undergrad student training: 1
  • Paper Published: 15

अनुसंधान अनुदान

DBT-Ramalingaswami Fellowship 2022 (Role of genome maintenance in placental development and pregnancy complications)

प्रकाशन

  • Singh V.P.*, Hassan H., Deng F., Tsuchiya D. , McKinney S., Ferro K. and Gerton J. L.*: c-Myc promotes polyploidy in murine trophoblast cells and suppresses senescence. Development, 2023 dev.201581. https://doi.org/10.1242/dev.201581 (*Co-corresponding author) (Cover Image- Development, 2023, Volume 150, Issue 11)
  • Singh V.P., Gerton, J.L.: Cornelia de Lange Syndrome and the Cohesin Complex: Abstracts from the 9th Biennial Scientific and Educational Virtual Symposium 2020 (Abstract). Am J Med Genet A. 2022, 188(3): 1005-1014.
  • Yueh, Wei-Ting, Singh V.P. and Gerton, J.L.: Maternal Smc3 protects the integrity of the zygotic genome through DNA replication and mitosis. Development 2021, 142(24) dev.199800. https://doi.org/10.1242/dev.199800
  • Gomes de Lima L., Howe E., Singh V.P., Potapova T., Li H., Xu B., Castle J., Crozier S., Harrison C.J., Clifford S.C., Miga K.H., Ryan S., and Gerton J. L.: PCR amplicons to determine human centromeric array copy number reveal wide-spread size variation and instability in cancer. Cell Genomics 2021, 1(3), 100064. https://doi.org/10.1016/j.xgen.2021.100064
  • Kusuhara A., Babayev E., Zhou L., Singh V.P., Gerton J.L., and Duncan F.E.: Immature Follicular Origins and Disrupted Oocyte Growth Pathways Contribute to Decreased Gamete Quality During Reproductive Juvenescence in Mice. Front. Cell Dev. Biol 2021, 9: 693742. https://doi.org/10.3389/fcell.2021.693742
  • Singh V.P.* and Gerton J. L.: Protocol for mouse trophoblast stem cell isolation, differentiation, and cytokine detection. STAR Protocols 2021, 2, 100242. (*Co-corresponding author)
  • Singh V.P., McKinney, S., Gerton J. L.: Persistent DNA Damage and Senescence in the Placenta Impacts Developmental Outcomes of Embryos. Developmental Cell 2020, 54(3):333-347. (Editor’s choice in Science Magazine - DNA repair in the placenta, Science 2020, 369 (6500):155-156 & preview by Vicente et. al., Keep Calm and the Placenta Will Carry On, Developmental Cell 2020, 54(3):295-296)
  • Singh V.P., Yueh W., Gerton J.L., Duncan F. E.: Oocyte-specific deletion of Hdac8 in mice reveals stage-specific effects on fertility. Reproduction 2019, 157(3):305-316.
  • Singh V.P., Gerton, J.L.: Cornelia de Lange syndrome, related disorders, and the Cohesin complex: Abstracts from the 8th biennial scientific and educational symposium 2018 (Abstract). Am J Med Genet A. 2019, 179(6):1080-1090.
  • Singh V.P., Katta S., Kumar S.: WD-repeat protein WDR13 is a novel transcriptional regulator of c-Jun and modulates intestinal homeostasis in mice. BMC Cancer 2017, 17:148.
  • Xu B., Li H., Perry J., Singh V.P., Unruh J., Yu Z., Zakari M., McDowell W., Li L., Gerton J.L.: Ribosomal DNA copy number loss and sequence variation in cancer. PLoS Genetics 2017, 13(6): e1006771. https://doi.org/10.1371/journal.pgen.1006771
  • Singh V.P., Gerton, J. L.: Cohesin and human disease: lessons from mouse models. Curr Opin Cell Biol 2015, 37:9-17.
  • Singh V.P.*, Alex J.L., Lakshmi B.J., Sailasree S.P., Raj T.A., Kumar S.*: Role of mouse Wdr13 in placental growth; a genetic evidence for lifetime body weight determination by placenta during development. Sci Rep 2015, 5:13371. (*Co-corresponding author)
  • Singh V.P.#, Gurunathan C.#, Singh S., Singh B., Lakshmi B.J., Mishra A.P., Kumar S.: Genetic deletion of Wdr13 improves the metabolic phenotype of Lepr (db/db) mice by modulating AP1 and PPARgamma target genes. Diabetologia 2015, 58(2):384-392. (# equally contributed)
  • Singh V.P., Lakshmi B.J., Singh S., Shah V., Goel S., Sarathi D.P., Kumar S.: Lack of Wdr13 gene in mice leads to enhanced pancreatic beta cell proliferation, hyperinsulinemia and mild obesity. PLoS ONE 2012, 7(6):e38685.